C3 method comparison

C3 method comparison

The complement system stimulates the inflammatory process and promotes the lysis ( rupture of the cell membrane of cells or bacteria that produces the exit of the cellular material) of these pathogenic microorganisms. And finally, the complement system also plays a role as a secondary messenger for the B-lymphocyte response and antibody synthesis.metodoc3n The C3 component is a protein that performs many functions in conjunction with other serum proteins, with cell surface receptors, and with membrane-associated regulatory proteins. Complement C3 deficiency gives rise to severe clinical manifestations, and reflects its important role in the activation of Complement C5 and in the formation of the MAC (Membrane Attack Complex). In patients with this immunodeficiency, the third component may be absent or only decreased. The severity of this disease depends on the degree to which C3 synthesis is compromised. C4 is a non-enzymatic component of the complement system that participates in the initial activation step of the classical pathway and its expression is determined by 2 pairs of allotypes: C4A and C4B.